Special Assignment D3 Vitamin

Methods

This study was a randomized-blinded clinical trial. Eighty-six women diagnosed with PCOS and vitamin D deficiency aged between 18 and 45 were enrolled. They were randomly divided into two groups of interventional (44 women) and control (42 women). In each group, patient assignment was done using randomized blocks of four. Based on the block combination, vitamin D at a dose of 50,000 unit per week (Interventional group) and a dose of 50,000 units per month (Control group) and elemental calcium at a dose of 1000 mg per day were administered by a nurse. Metabolic parameters (i.e., LDL, HDL, total cholesterol, HOMA-IR, serum insulin, FBS, TG) and serum vitamin D were measured at baseline and 2 months after treatment.

Results

In vitamin D group, serum levels of 25 (OH) D increased. There was no significant difference in the metabolic parameters before and after treatment in each group (P > .05). At the end of the study, the metabolic parameters and HOMA-IR did not show a significant difference.

Conclusion

This study showed that vitamin D replacement in women with PCOS and vitamin D deficiency has no effect on the improvement of metabolic parameters and HOMA-IR.

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